Cart
sales@molnova.com
Home - Products - Angiogenesis - HIF/HIF Prolyl-hydroxylase - HIF-2α agonist 2

HIF-2α agonist 2

CAS No. 2750141-15-0

HIF-2α agonist 2( —— )

Catalog No. M36012 CAS No. 2750141-15-0

HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reha-Luc cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 78 Get Quote
5MG 116 Get Quote
10MG 187 Get Quote
25MG 365 Get Quote
50MG 542 Get Quote
100MG 759 Get Quote
500MG 1557 Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    HIF-2α agonist 2
  • Note
    Research use only, not for human use.
  • Brief Description
    HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reha-Luc cells.
  • Description
    HIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agonist 2 is non-cytotoxic against 786-O-HRE-Luc cells. HIF-2α agonist 2 can be used for oxygen metabolism research.
  • In Vitro
    Cell Viability Assay Cell Line:786-O-HRE-Luc cell line Concentration:0.003-20 μM Incubation Time:24 hours Result:Showed no cytotoxicity to 786-O-Luc cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    HIF/HIF Prolyl-hydroxylase
  • Recptor
    HIF | HIF/HIF Prolyl-Hydroxylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2750141-15-0
  • Formula Weight
    416.09
  • Molecular Formula
    C13H8Br2N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (240.33 mM; Ultrasonic (<60°C)
  • SMILES
    N(C=1C=2C(S(=O)(=O)N1)=CC=CC2)C3=CC(Br)=CC(Br)=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yu Y, et al. Insight into the binding mode of HIF-2 agonists through molecular dynamic simulations and biological validation. Eur J Med Chem. 2021 Feb 5;211:112999.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • BAY 87-2243

    BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. Phase 1.

  • PT-2399

    PT-2399 (PT 2399, PT2399)?is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain.

  • HIF-2α-IN-3

    HIF-2α-IN-3 is a HIF-2α alteration inhibitor with anti-tumor properties and may be used in the study of cardiovascular disease.

Sign In Join Free